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DAVID analysis of all regulated genes and transcripts found by the two analysis techniques yielded 174 common GO-categories (supplemental data, Table S2; cut-off p-value 0.05) again demonstrating the significant common core of both data sets.
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In our previous study, we identified 28 significant proteins--i.e., common core network markers--of four types of cancers as house-keeping proteins of these cancers.
Common Core is not the common enemy.
Although we used unique gene datasets to search for tissue-specific motifs, the body muscle and pharynx shared several highly significant sequences, suggesting the existence of common core regulatory elements modified for pharynx and body muscle (Table S6 in Additional file 1).
But the highly touted Common Core exams are not a significant improvement.
As the common core predicted, we could detect significant amounts of IFN-γ in the systemic circulation of rats with an ongoing local kidney infection.
When it was mainly the same country which deviated most from the common core when there were statistically significant interactions then all analyses just described were repeated without the data from this country.
Cancer is a complex disease, and so we tried to reveal house-keeping proteins significant in different cancers, i.e. the common core network markers shared by the different cancers.
If a significant proportion of these detected unannotated transcripts were random artifacts, we would expect the common core to show a lower proportion of known annotated transcripts.
However, the broad relationship between mRNA stability and induction kinetics is not merely explained by this common core set of rapidly induced genes, as the relationship remained highly significant also after the removal of this core set from the analysis (Additional file 4, data not shown).
The 28 significant proteins in Figure 1(a) (see also Table 1) are significant proteins shared by the four cancers, and these proteins and their PPIs form the common core network markers of these four cancers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com