Sentence examples for significant clinical difficulty from inspiring English sources

As patients with ADPKD and CKD1-4 are typically seen in the nephrology out-patient clinic setting that does not include those with CKD5 and ESRF, this should not present significant clinical difficulty.

However, significant clinical challenges remain, including difficulties with treatment adherence, side effects, contraindication in pregnancy, development of resistance mutations and the significant health-care costs of providing potentially lifelong therapy in a disease where the prevalence in the United States is predicted to increase six-fold from pre-TKI levels by 2035.

Venous malformations in the tongue cause significant clinical problems such as swallowing difficulties and speech and airway obstruction.

Repair and healing of injured and diseased tendons are traditionally a significant clinical problem, fraught with apprehension and difficulties, and often result to rather inconsistent outcomes.

Though these invasive BMIs have made great success, they face substantial technical difficulties and entail significant clinical risks: they require that recording electrodes be implanted in the cortex and function well for long periods, and they risk infection and other damages to the brain.

The idiotype vaccine for B cell lymphoma and the whole cell vaccine for colon cancer showed statistically significant clinical activity, but are encumbered by difficulties in vaccine production or regulatory concerns about vaccine quality.

There were no significant clinical factors that accounted for the procedural difficulty in the two failed attempts.

The program also includes a significant clinical training component.

International viewpoints on topics of significant clinical importance.

Brain metastases are a significant clinical challenge.

A significant clinical response appeared by week 6.