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The Israeli military also recently removed several significant checkpoints inside the West Bank, in line with a policy of easing movement and improving daily life for the Palestinians so long as calm prevails.
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The border is a significant checkpoint on the journey towards south-east Europe.
At the same time, the company "eliminated every significant checkpoint on loan quality and compensated its employees solely based on the volume of loans originated, leading to rampant instances of fraud and other serious defects," Bharara alleged.
After Kurland's departure in late 2006, to boost production, Countrywide "eliminated every significant checkpoint on loan quality and compensated its employees solely based on the volume of loans originated, leading to rampant instances of fraud," according to a civil complaint filed last year by the Justice Department against Bank of America, which purchased Countrywide in 2008.
Consistent with the idea that Apc2 does not participate in the centrosome orientation checkpoint, apc2 mutants also maintained significant checkpoint activity.
Furthermore, unlike T-cell autoreactivity, the development of B-cell autoreactivity towards citrullinated epitopes appears to be a significant checkpoint in the progression to RA.
Although the kinetochore has been of tremendous interest in checkpoint dynamics, a significant portion of checkpoint activity also takes place through cytoplasmic interactions that remain poorly understood.
A significant number of checkpoint proteins have been identified but how they orchestrate the communication between local spindle attachment and global cytoplasmic signalling to delay segregation is not yet understood.
In the HCT116 and Caco-2 lines, this resulted in activation of the spindle-assembly checkpoint and significant M phase arrest.
This could lead to more significant damage which activates other checkpoints to cause the S phase stop.
The activation of cell cycle checkpoints plays a significant role in the DNA damage response.
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