The excel add-in software SAM (Significance Analysis of Microarray) [ 34] was used to perform pair-wise comparisons of all conditions, identifying 1,995 significant changes, representing 775 genes whose expressions were either responsive to EGF and/or HRG, genes differentially regulated by ErbB2 overexpression, or both.
Furthermore, the use of the two criteria to evaluate clinically significant change represents a more stringent measure than most of the previously used criteria.
There is disagreement on whether commonly occurring exposures in welding, ferroalloy, and other industrial processes produce neurologically significant neurobehavioral changes representing parkinsonism.
Hundreds of genes showed statistically significant expression changes, representing several functional categories including cell specification, differentiation, morphogenesis, proliferation, epigenetics, and retinol metabolism (Table 3).
Table 2 indicates the proportion of the comparisons with significant changes that represented increased activity for the PA task, about half of the fMRI and single neuron changes and a larger proportion of the LFP changes (67% 82%).
Moreover, HA molecular analysis showed, in four out of five SIVs, a unique significant AA change, represented by 2-AA-insertion at the HA receptor binding site (RBS).
Additionally, our approach is based on an explicit hypothesis that phenotypic changes represented by significant transcriptomic changes respond to cancer driver mutations.
The insets show small, but significant changes (values represent the average of 5 different experiments +/− SD) at the level of the secondary structure of aSyn, in agreement the conformational changes observed in neuronal cells, where the distance between the N- and C-termini of aSyn is modified by DA treatment.
Advocates need to counter that changes represent "significant improvements over what we have" in terms of simplicity, fairness and efficiency.
The changes represent significant improvement, though not the wholesale transformation the franchise once envisioned.
