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The phrase "significant changes in" is correct and commonly used in written English.
It can be used to refer to important or notable modifications or differences in a particular situation or topic. Example: "There have been significant changes in the company's policies regarding employee benefits."
Exact(56)
Significant changes in society create significant changes in the lexicon.
Two consecutive bad years forces significant changes in spending.
Drought has already spurred significant changes in Australia's agricultural heartland.
There are significant changes in the city's northern suburbs.
Both sides have undergone significant changes in personnel since.
Like the Yankees, they have made significant changes in their rotation.
In practice, you see significant changes in people as they work with the horses".
The company does not expect significant changes in the work force, Mr. Schatz.
He left any significant changes in policy to the next president.
The business of appraising has seen significant changes in recent years.
"But we've seen significant changes in the UK restaurant scene over the last year.
More suggestions(20)
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momentous changes in
appreciable changes in
prominent changes in
remarkable changes in
sizeable changes in
significant modifications in
sizable changes in
noteworthy changes in
considerable changes in
salient changes in
notable changes in
huge changes in
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tangible changes in
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substantial changes in
vital changes in
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com