The significant higher centrality of the HDF sub-network shows that it takes on a central position within the total human protein interaction network.
While the individual fold changes of these molecules were not necessarily always significant, their centrality within the networks indicated that they were key modulators of A20's effects on liver regeneration.
D shows 7 terms for cellular components with significant transitivity centrality between the S. cerevisiae GRNand PPN.
As seen in Figure 3, AKT was also identified as a connected gene, and had significant betweenness centrality and degree values (shown in Table 3), indicating that AKT has potential to act as a "hub node" in biological interaction networks and be involved in chemoresistant mechanisms as well [ 40].
Among 8 pathways evaluated as insignificant by traditional ORA but significant by centrality-based methods, four have been previously linked to liver cancers [ 42, 44, 45].
Again, the correlations are negative and significant for degree centrality (τ = -0.16, P = 0.01) and marginally significant for betweenness centrality (τ = -0.12, P = 0.05) (Additional file 1, Figure S4), which is consistent with previous results, even though we are restricting our analyses to much fewer genes.
It boosts technological innovation in companies in its environment; in all networks, it acts as one of the bridging nodes and it has a significant degree of centrality.
It highlights the position of UdL, with strong ties to several companies; it has a significant degree of centrality, which allows it to exert some influence on the network (Table 3) and, in turn, it has the highest degree of intermediation, which ranks it as one of the bridging agents.
In contrast, we find no significant relationship between centrality and drug use (see Text S1).
The potential biological relevance of the genes identified as significant with the centrality scores was first estimated through an enrichment analysis of Gene Ontology (GO) terms.
