Sentence examples for significant build up from inspiring English sources

It is conceivable that the reduced PCMT activity in PAEC transfected with antisense or PCMT mutants may determine a significant build up of isoaspartyl-containing damaged proteins.

ARK2 data revealed that there is a significant build up in the G0/G1 phase of the cell cycle with even low levels (25 n M) of afatinib compared with untreated samples mean 42.6±0.20% vs 30.4±0.32% (P=0.001).

This may have contributed to a significant build-up of NO3− as effluent moved towards groundwater largely due to inhibited denitrification and the mobilization and remineralisation of previously assimilated DON.

"The significant build-up of risks throughout last year, linked to the slowdown in the global economy, loom large for manufacturers as we go into 2016, with no sign that slowing export demand, the strength of the exchange rate and volatility in major markets will soon ease," he said.

CO _2) free energy requires a significant build-up of nuclear and/or renewable power production, which involves large initial economic investments [3].

While other popular content marketing strategies require significant build-up before results can be seen, PPC can be turned on and off with the click of a mouse.

As we've mentioned several times in recent issues, there has been a significant build-up in corporate debt over the last few years.

Heavy metals show a significant build-up with contamination and long-term accumulation of heavy metals in soils has led to contamination of food crops in the study area.

Nor do the regulars seem to show a significant build-up of long-term damage – like scar tissue in the heart's muscles or excessive wear and tear to their joints – that some had expected.

However, we note that in solubilized mitochondria from yme1Δ tim9cells cells, a significant build-up of monomeric Tim10, but not Tim9 was observed in [ 24].

By 3 h, the MR spectra showed a steady decrease in NTP and NAD, and a significant build-up of fructose 1,6-bisphosphate (F-1,6-P) dihydroxyacetonephosphate and glycerol-3-phosphate, indicating modulation of glycolysis.