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But she believes a significant breakthrough is near.
The agent that should be considered a significant breakthrough is definitely vemurafenib, a highly specific inhibitor of the BRAF kinase that harbours the mutation V600.
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Marconi's most significant breakthrough was yet to come.
An unexpected yet significant breakthrough was the discovery of a link between RNAi and transcriptional silencing in fission yeast (Volpe et al., 2002).
Recently, a significant breakthrough was made when some research groups showed that graphite could be exfoliated by non-chemical solution phase methods with solvents[11 13] or surfactants[14, 15].
For assessing the potential of a chemical to be toxic, a significant breakthrough was the creation of cheap and short-term alternatives to the rodent bioassay, the main tool of the research on chemical carcinogens.
R1128 also resolves the contradictions of giant panicle and lower seed setting rate in previous generations when a significant breakthrough was achieved in creating hybrid rice parents through wide crosses between subspecies.
The most significant breakthrough was Sjöstrand's discovery [240] of geometric upper bounds on the number of resonances in which the exponent is no longer the dimension as in (2.26) and (2.29) but depends on the dynamical properties of the classical system.
Though no significant breakthrough was expected out of the Singh-Sharif meeting, that fact that it was even taking place sends a positive signal to both countries, analysts said, while canceling it reverses hope of modest progress anytime soon.
A significant breakthrough was achieved when the study of membrane protein conformation became possible.
A significant breakthrough was achieved through filter papers for the diagnosis of diseases, genotyping and sero-surveillance.
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