Exact(12)
It was found that metal-NOM binding is primarily driven by electrostatic attraction between the positive ions and the negatively charged carboxylate groups of the NOM molecule (whereas phenolic groups were not significant binding sites).
Due to a fundamental problem of hypothesis testing approaches, they are prone to systematically finding more significant binding sites in longer promoter sequences just by chance.
This analysis identified several conserved and significant binding sites.
Significant binding sites within 2 megabases from the miRNA SSS were selected as potential candidates.
This latter graph identifies E2F, E2F1, CBF, ETF, WHN, VMYB, ELK1, and CETS1P54 as highly significant binding sites.
A peak finding algorithm with false discovery rate (FDR) analysis (PERL script available on request) was developed to identify significant binding sites.
Similar(48)
In addition, 12 currently unannotated proteins were also screened, resulting in a large number of statistically significant binding site matches, which could suggest likely functions for these uncharacterized proteins.
De novo motif discovery was performed for TFs with significant binding site enrichment and for 20 TFs with no known binding characterization.
There was no significant binding site capture from brains of α4 KO or β2 KO mice.
Nonconserved miR-1279 interaction sites in these genes had Δ G/Δ G m values ranging from 62.0% to 80.5%, and only the MLH3 gene had a significant binding site (Δ G/Δ G m value is 73%).
To predict SigB regulon structure in each organism, the SigB HMM and PWM were used to independently scan across all 20 Bacillus genomes, and TUs 3' to a significant binding site were extracted.
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