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"significant applications" is a correct and usable phrase in written English
You can use it to refer to applications or uses of something that are significant, or noteworthy, in some way. For example, "We are seeing significant applications of machine learning in the healthcare industry."
Exact(60)
Some of the more significant applications are described in this section.
When it comes to technology's most significant applications, we are neither usurped or seduced – because the systems involved are nothing like us in either their function or faculties.
(Generally, examiners spend somewhere between eleven and twenty-two hours per patent, and no extra time is allocated for commercially significant applications).
Other significant applications include the use of radioactive isotopes as compact sources of electrical power e.g., plutonium-238 in spacecraft.
Other cobaltous salts have significant applications in the production of catalysts, driers, cobalt metal powders, and other salts.
Nonlinear optics has many significant applications in communications and photonics, information processing, schemes for optical computing and storage, and spectroscopy.
Spearheads were also among the earliest militarily significant applications of iron, no doubt because existing patterns could be directly extrapolated from bronze to iron.
To do this he introduced a new technique known as forcing, a technique that has since had significant applications throughout set theory.
Face recognition has significant applications for defense and national security.
Possible significant applications of the method are also discussed.
Biharmonic equation has significant applications in physics and engineering.
More suggestions(15)
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significant proposals
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com