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"significant appearance" is a correct and usable phrase in written English.
It is typically used to describe a noteworthy or important presence or manifestation of someone or something. Example sentence: Her significant appearance at the meeting caught everyone's attention.
Exact(40)
We considered a biologically significant bicluster as one that is relevant to at least one GO term with a statistically significant appearance (namely, Padj less than significance level).
It showed a significant appearance in principal component 3 and no other element appeared in that factor.
In that story, Phoebe makes a brief, but significant, appearance at the end.
Now the Jets' top draft pick begins to prepare for another significant appearance -- Monday night against the Patriots at Giants Stadium.
December 2006: Kate makes her most significant appearance to date as she turns up to watch William graduate as an Army officer at Sandhurst.
However, many studies have failed to provide sufficient quantitative data to proof passage of the BBB and significant appearance of drugs inside the brain parenchyma.
Similar(20)
A few contemporary colloquial phrases make subdued but significant appearances in the text.
Arguably, Cox is the most famous: a well-known face in Hollywood, the Dundonian was the first actor to play Hannibal Lecter in 1986's Manhunter, and has made significant appearances in action franchises like the Bourne, Red and X-Men films.
It has made significant appearances in at least five novels, including John Irving's A Prayer for Owen Meany, and it continues to be pored over by historians, social scientists, and graduate students.
He added, "I think play is more significant than appearance.
Sidney made one last significant TV appearance, in the TV movie "A Gathering of Old Men".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com