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The physiologically connected reactions, i.e. biologically significant and functional modules of network, were identified by metabolic pathway analysis.
We found that the intracellular superoxide levels in 5-FU-treated AGS KD cells were 2.5-fold higher than those in 5-FU-treated AGS SCR cells (Figure S5), indicating that functional inactivation of HIF-1α in AGS cells resulted in significant and functional elevation of intracellular oxidative stress even under chemotherapeutic treatment.
Correspondingly, although the tramadol intake was lower in etanercept compared with placebo-treated patients, the difference was not statistically significant, and functional status as evaluated by HAQ did not improve in any of the groups.
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Functional indices were weakly related between each other and only two correlations were significant and positive (functional divergence and first PCoA axis, functional richness and second PCoA axis).
The uremic leontiasis ossea causes significant aesthetic and functional changes.
Tumor microenvironmental features bear significant structural and functional constraints to effective nanomedicine delivery.
Calcified rotator cuff tendinitis is a common cause of chronic shoulder pain that leads to significant pain and functional limitations.
Upon activation, T cells undergo significant morphological and functional changes, putting new metabolic demands on the cell.
Congenital heart diseases causing significant hemodynamic and functional consequences require surgical repair.
Loss of motion after ACLR causes significant pain and functional impairment [5].
Most congenital heart diseases causing significant hemodynamic and functional consequences require surgical repair.
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