"significant amount of changes" is correct and can be used in written English.
You can use it to refer to a large number of changes that have been or need to be made. For example, "Due to the current circumstances, we will need to implement a significant amount of changes to our operations."
Future precipitation changes under different GHG (greenhouse gas) emission scenarios also projected with the developed downscaling model that reveals a significant amount of changes in future seasonal precipitation and number of wet days in the river basin.
"A significant amount of changes have been made since the storm," she told HuffPost.
However, the study also revealed that significant amount of changes triggered by 20 μM glutamate (53/106 upregulated genes and 10/51 downregulated genes) overlapped with those triggered by bicuculline.
In newborns and toddlers, there is development of the liver; there are changes in blood flow to the skin and the lungs; the kidneys develop; and, certainly, the brain goes through a significant amount of change.
While the Creative Society had been "establishing itself as a successful and sustainable social enterprise, the banking sector has seen a significant amount of change requiring us to review all of our special charging arrangements".
But Liam Byrne, chief secretary to the Treasury, said: "We think we can merge a lot of the more routine functions in departments to save money – and £11bn is a figure not to be sniffed at, it's a significant amount of change".
The company has been through a significant amount of change over the past few months.
The 75:25 albumin-water plastics showed the most significant amount of change: the modulus drastically increased after 5 days of conditioning (initial = 2.5E8 Pa, 5 days = 1.8E9 Pa) with lower initial tanδ values (initial = 0.23, 5 days = 0.09), and the tanδ peak shifted to the right (Figure 4 Van Soest and Knooren 1997).
These studies suggest that there is a significant amount of change within ICN throughout the lifespan.
Except for a few characteristic motifs, each of the SIBLING orthologs undergoes a significant amount of change.
Given that the US, characterized as an individualistic culture, is very different than the collectivistic Turkish culture, we expected that participants would experience a significant amount of change in their expectations and attitudes toward romantic relationships.
