When seeded in HNE-treated Coll II, significant amendment of chondrocyte morphology, from the typical chondrocyte-like polygon shape to rounded, semi-detached cells, was observed; mainly when Col II was modified by HNE at a 1 200 MR (Col II:HNE).
In the event of changes to study design requiring significant amendment to the content of the participant information sheet, participants will be required to provide renewed informed consent.
The most recent significant amendment to the Act was passed in 1974, removing the exemption of nonprofit hospitals.
The recent Coroners and Justice Act – to mention just one of many – contained significant amendments to the law on murder, mercy killing, manslaughter and assisted suicide.
The European Parliament has proposed numerous, significant, amendments to the original proposal, only some of which have been incorporated into the Commission's amended proposal.
On October 26, 2011, the Securities and Exchange Commission SECC) approved proposed Rule 204(b -1 under the Investment Advisers Act of 1940, with certain significant amendments to the original proposal issued in January.
Two significant amendments to the Food, Drug, and Cosmetic (FD&C) Act were introduced during the period of analysis: The Food and Drug Administration Modernization Act of 1997 (FDAMA) and the Food and Drug Administration Amendments Act (FDAAA) of 2007.
He made some significant amendments to the new ban.
After the composer's death the score was subject to significant amendment, including the introduction of recitative in place of the original dialogue; there is no standard edition of the opera, and different views exist as to what versions best express Bizet's intentions.
