"significant alter" is correct and usable in written English.
You can use it to describe a change that has an important or meaningful impact on something. For example, "The new regulation represented a significant alter to the status quo."
The position effects are significant, altering the mean protein expression level by up to 15 times and expression noise by up to 20 times.
Notice the stronger underestimation and change in the overall shape for all latitudes clearly visible in September 2009 when the state of the GOME-2 instrument was significant altered after a throughput test.
Voxel-based texture features analysis over the whole brain was performed between MOH and NC, and two-sample t-test design model was selected to identify the brain regions with significant altered texture features in MOH.
A methylated DNA immunoprecipitation with methyl-cytosine antibody followed by a promoter tilling microarray (MeDIP-Chip) procedure was used to identify 52 different regions with statistically significant altered methylation in the sperm promoter epigenome.
We hypothesized that (1) significant altered microstructural integrity occurred in the symptomatic acute TBI.
In conclusion, we can demonstrate that miR-155 is one of the most significant altered miRNAs in breast cancer.
This pathway, and more specifically the "intrinsic and extrinsic prothrombin activation" subgroups, is the most significant altered pathway.
16% of the discordant diagnoses were considered to be clinically significant, altering patient management and/or prognosis.
Characterization of a SCA 1 transgenic mouse model also indicated changes in the autophagic flux by vacuolar formation with autophagic origin and significant altered LC3-II/-I ratio [ 204].
Male most significant altered regions contained genes involved in cell communication, cell division and immunological response, while female cell cell junction maintenance, regulation of transcription and neuron development.
