Bisphenol AF is a potent binder of ERα and ERβ and thus would perturb these physiological processes, perhaps providing significant adverse influences for the central and peripheral systems.
The most significant adverse prognostic factors influencing long-term survival in the patient group examined were involvement of local lymph nodes and the inability to achieve a complete resection, confirming results of previous studies (Lieberman et al, 1995; Dexter et al, 2001; Butsch et al, 2002; Hofstetter et al, 2002).
13 Moreover, even small amounts of Western influence in diet are associated with significant adverse alterations in metabolic and physiological markers, often before any substantial lifestyle changes.
Delayed diffusion processes become increasingly significant during rapid glucose oscillations [30, 33] and may contribute to the adverse influence of glucose variability and hyperglycemia on sensor performance.
Drainage of 10 m downstream of the wetland resulted in a localized zone of influence within half a kilometer from the drainage site with significant adverse impacts on groundwater and biomass levels, indicating a strong need for conservation.
The presence of aneuploidy in at least one sample from a tumour was a significant adverse prognostic factor (P < 0.001), whereas the degree of heterogeneity had no influence on survival.
This means that significant adverse events will be analyzed under "real-life conditions", i.e. without influencing the prescription behavior of the physicians or the desires of the women.
In DSM IV, the definition of Substance Abuse is "a maladaptive pattern of substance use manifested by significant adverse consequences" in at least one of four different domains of trouble: 1) driving under the influence; 2) other legal problems (e.g., disorderly conduct, assault, etc).; 3) reduced performance at work or school, and; 4) problems with interpersonal relations and family life.
38 A recent systematic review and meta-analysis of observational studies that examined influence of caesarean delivered on early breastfeeding showed that caesarean delivery has a significant adverse association with early breastfeeding.
