Sentence examples for significant added toxicity from inspiring English sources

A future goal could be represented by the introduction of targeted therapies to improve disease control without significant added toxicity.

The previously untreated patients in the current study might be expected to have a more favourable outcome from cetuximab alone; however, it is possible that rIL-21 has contributed to the disease stabilisation in these patients without significant added toxicity.

The addition of cisplatin added toxicity without improving efficacy.

Despite a 20% dose reduction for both drugs in subsequent patients, there were still concerns of significant toxicity, particularly haematologic and CNS, leading investigators to conclude that, addition of ifosfamide to cisplatin despite offering a small improvement in PFS over ifosfamide alone, the added toxicity may not justify the use of this combination (Sutton et al, 2000).

Recently, O'Connell et al. [ 29] reported that adding oxaliplatin did not improve the rates of pCR, sphincter-sparing surgery, or surgical down-staging; instead, oxaliplatin added significant toxicity.

Bevacizumab has been the most active targeted therapeutic for GBM as a monotherapy but fails to increase overall survival for newly diagnosed or recurrent patients, and adds significant toxicity.

We're doing significant added-value.

The addition of 5FU/IFN failed to increase the efficacy and added new toxicity (myelosuppression).

The objective is rather to determine that no significant toxicity is added to that intrinsic to tobacco smoke, either of the same type or new.

While some changes with sugar application were detected, the overall evaluation of all data considered on a weight-of-evidence basis suggests that the use of sugars would "add no significant toxicity to tobacco products and therefore could be considered safe in the context of this use" (stipulation taken from the US Institute of Medicine, 2001).

The US Institute of Medicine described some regulatory principles, which include the use of appropriate toxicological testing methods "with the objective of identifying those ingredients that add no significant toxicity to tobacco products and therefore can be considered safe in the context of this use" (US Institute of Medicine, 2001).