Sentence examples for significant activators of from inspiring English sources

Our data thus suggest that signaling of FGFR3 mutants towards STAT5 is similar to STAT1, i.e. only the K650M and K650E-FGFR3 are significant activators of STAT5.

Taken together, we demonstrate that only K650M and K650E-FGFR3 mutants represent the only significant activators of STAT1 among the mutants studied here (Figs 1 3).

As previously observed, the capillary density was significantly reduced in animals with pressure-overload hypertrophy [16]; however, hypoxia (normally a significant activator of angiogenesis) did not induce increased vascularization in hypertrophied hearts.

Along with the present studies in C. elegans, these data suggest the intriguing hypothesis that cellular osmotic stress may be an evolutionarily conserved and physiologically significant activator of immune responses.

However, the urokinase plg activator (uPA) is widely accepted as the most significant activator of plg during tissue degradation [ 5, 6].

Unmethylated CpG containing DNAs released from bacterial cells have also emerged as a significant activator of liver innate immunity (Petrasek et al. 2013; Seki and Schnabl 2012).

We conclude that BADGE is not a significant activator of PPARγ and instead facilitates adipose conversion of the MSCs through a pathway that is unlikely to be PPARγ mediated.

We demonstrate significant activation of both signal transducer and activator of transcription (STAT 3 and its upstream activator Janus kinase (JAK 2, in high-grade ovarian carcinomas compared with normal ovaries and benign tumours.

HMU00160 encodes a predicted protein with significant homology to haemolysin activators of diverse gram-negatives including Photorhabdus luminescens, Burkholderia pseudomallei, and a pathogenicity-island encoded determinant of E. coli [ 63].

CI, confidence interval; NS, not significant; STAT, signal transducers and activators of transcription.

The ability of HSF1 overexpression to attenuate pathologic imbalances in intracellular proteostasis associated with these diseases has led to significant effort to identify small-molecule activators of HSF1.