Sentence examples for significant activator of from inspiring English sources

As previously observed, the capillary density was significantly reduced in animals with pressure-overload hypertrophy [16]; however, hypoxia (normally a significant activator of angiogenesis) did not induce increased vascularization in hypertrophied hearts.

Along with the present studies in C. elegans, these data suggest the intriguing hypothesis that cellular osmotic stress may be an evolutionarily conserved and physiologically significant activator of immune responses.

Unmethylated CpG containing DNAs released from bacterial cells have also emerged as a significant activator of liver innate immunity (Petrasek et al. 2013; Seki and Schnabl 2012).

However, the urokinase plg activator (uPA) is widely accepted as the most significant activator of plg during tissue degradation [ 5, 6].

We conclude that BADGE is not a significant activator of PPARγ and instead facilitates adipose conversion of the MSCs through a pathway that is unlikely to be PPARγ mediated.

Our data thus suggest that signaling of FGFR3 mutants towards STAT5 is similar to STAT1, i.e. only the K650M and K650E-FGFR3 are significant activators of STAT5.

Taken together, we demonstrate that only K650M and K650E-FGFR3 mutants represent the only significant activators of STAT1 among the mutants studied here (Figs 1 3).

We demonstrate significant activation of both signal transducer and activator of transcription (STAT 3 and its upstream activator Janus kinase (JAK 2, in high-grade ovarian carcinomas compared with normal ovaries and benign tumours.

This conclusion is based on several lines of evidence that DDB2 is highly expressed in the human ER-positive breast tumor samples and in the cell lines we examined, compared to ER-negative status, and plays a significant role as an activator of growth, favouring G1/S transition entry of ER-positive breast cancer cells during their cell cycle.

This is significant inasmuch as CO2 appears to be an important long-range activator of mosquito host-seeking (Gillies 1980; Takken and Knols 1999).

Overall, we conclude that NFI more prominently binds the TSS of the up-regulated genes as compared to non-regulated or down-regulated genes, implying that NFI is a direct activator of a significant subset of the up-regulated target genes.