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The phrase 'significant accumulation of' is correct and usable in written English
It can be used to describe a large and meaningful number and/or amount of something. For example, "The team's win streak has resulted in a significant accumulation of points in the standings."
Exact(60)
The result was clear — no significant accumulation of plaques.
Below the surface horizon lies a region with significant accumulation of translocated (migrated) layer silicate clay.
The defining characteristic of the spodic layer is the significant accumulation of iron- and aluminum-bearing minerals intermixed with humus.
Significant accumulation of voids around both the layer interfaces and yarn fibres were also observed.
Cadmium exposure caused significant accumulation of the cadmium and iron in mice hearts tissue.
Treatment with ABA at fruit set entrains a very rapid and significant accumulation of lipids in the olives.
But in case of LPE-exposed fish, significant accumulation of Cr was noticed in most of the tissues (Table 2).
The results revealed a significant accumulation of intermediates of PPP, indicating a slowdown of the metabolic flux [25].
CT (15 mg/L) and CFC-11 (25 mg/L) were also biodegraded without significant accumulation of halomethane daughter products.
The experiment demonstrated that the in-span plastification caused a significant accumulation of plastic incremental deformations of HBEs.
The study of the break-in process revealed that significant accumulation of the solution species occurs in the neutral films.
More suggestions(15)
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tremendous accumulation of
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major accumulation of
appreciable accumulation of
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com