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There have been no unanimous criteria for declaring such replication in circumstances in which no SNP provides "genome wide significance" with the same phase of association in "template" GWA analyses of data from multiple independent samples.
Patients form Cork and Dublin were analyzed separately and then together – as both patient cohorts achieved significance with the same pattern.
The slopes of the best-fitted lines in wild-type and Tg Dyrk1a samples were analysed for statistical significance with the same software.
An expected exception is immobility in the open field, for which the QTL on chromosome 6 is reduced to suggestive level of significance with the same allelic effects.
The function in CGPredictor can also be used to efficiently test the extracted predictor's significance with the same default of 1,000 iterations (see Table 4).
Patients from the two different sites, Cork (n = 50) and Dublin (n = 102), were initially analyzed separately and then together for all parameters, as both patient cohorts achieved similar significance with the same assessment.
Similar(54)
In particular, we set and tested the significance of with the same LRT described next.
Graphs were constructed using Graphpad Prism 5 software, and statistical significance was calculated with the same program.
They were also less likely to delay surgery in order to have test results available for surgical decision-making and more likely to manage a patient with variants of uncertain significance in the same way they would manage patients with proven high-risk mutations in cancer-associated genes.
There is no consensus concerning criteria for declaring "replication" of GWA results in the absence of genome wide significance for the same SNP with the same phase of association in multiple independent samples [18] [23].
"Replication" of GWA results in these "template" GWA analyses is based on identification of genome wide significance for the same SNP with the same phase of association in each of multiple independent samples.
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