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The phrase "significance with" is grammatically correct and can be used in written English. It is typically used to indicate the importance or meaning associated with something or someone. Here is an example of its usage: The new law had no significance with the citizens until they realized its impact on their daily lives.
Exact(60)
He too telegraphs profound significance with exquisite skill.
Their meetings take on added significance with Carlsen's controversial withdrawal from the world championship cycle.
But it's also compulsively readable, and bears its load of significance with effortless power.
"Something happened with the significance with which law was taken," he said.
This bold strategy took on even greater significance with an opener in the 55th minute.
These differences might have reached the significance with higher number of pairs and statistical power.
There was a trend towards statistical significance, with PTEN methylated patients having decreased survival (P = 0.128).
Hydrograph peak discharge estimation is gaining more significance with unprecedented urbanization developments.
- but I now wonder if there is a macabre significance: with war approaching were people rapidly converting currency into gold?
It was from Brecht that he learned that each stage picture must combine significance with aesthetic beauty.
Both Bonny and Okrika have grown in significance with the exploitation of oil and natural gas in the Niger Delta.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com