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In contrast, the statistical significance procedure utilized by Protocol II (see Materials and Methods section) uses a repeated split cross-validation estimator effectively eliminating uncertainty introduced by non-representative splits.
First, our evaluation reveals that SDPpred performs better than MI in the PR evaluation; this is interesting, as the only difference between the two is the column shuffling significance procedure applied by SDPpred to adjust the MI score.
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The sample sizes and the power of the study including the reasoning for their choice, the level of significance, procedures to deal with missing data or errors in measurement should be clearly outlined.
The prediction method and the statistical significance procedures are described in the Methods section and the Supplement (Text S1 and Figure S1).
A number of different statistical significance procedures were evaluated but a blockwise bootstrap proved superior.
Test Xk for significance, stop procedure if Xk is not significant otherwise accept Subtract Xk from X Apply backfitting for each obtained plaid cluster Apply pruning to remove ill fitting metabolites and continue at step 2 The above algorithm is the original Plaid algorithm.
In summary, the significance test procedure was conducted as follows: (1) calculate βD βC from the original sample; (2) conduct the bootstrap procedure to estimate the 1-α percentile bootstrap CI, bias-corrected CI and calculate var βD) and var βC) by four different methods; and (3) reject the null hypothesis if the CI does not include zero or the p value less than the significance level α.
In contrast, the number of fatalities is available for almost all flood events in the database and a negative trend of at least 1% per year is observed, even though it is only statistically significant for the period between 1950 and 2016 (see Methods section for statistical significance testing procedure).
Significance: This procedure uses a technique familiar to otolaryngologists and may be used for pituitary and other skull base tumors.
A post hoc Fisher's Least Significance Difference procedure was employed for all findings, with a statistical significance level set at p < 0.05.
However, the most computationally intensive part of the significance assessment procedure is step 3(c).
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