Sentence examples for significance our knowledge from inspiring English sources

Despite its significance, our knowledge on molecular, cellular and environmental mechanisms that drive disease pathogenesis remains largely elusive, and there are limited therapeutic options, with only negligible clinical benefit.

This find has major significance for our knowledge of how this group of dinosaurs evolved".

However, to our knowledge, significance of the other SLAC1 phosphorylation sites has not been analyzed in vivo.

To the best of our knowledge, the significance of cell-associated melanin in the synthesis of AgNPs has not been reported earlier.

To the best of our knowledge, its significance as a prognostic marker in GIST has not been investigated.

Nonetheless, to our knowledge, the significance of p16INK4a overexpression has not been described before separately for HPVDNA+ and HPVDNA− OSCC.

To our knowledge, the significance of Skp2 over-expression as a prognostic marker in GIST has not been previously investigated.

To our knowledge, the significance of the prognostic value of a single monosomy in MK-AML has not been reported.

Within observational studies, clear definitions of drug exposure and risk attribution, as well as reporting of effect sizes, irrespective of statistical significance [ 99], would advance our knowledge.

Little is known about the role of prokineticins in human cancer, and to our knowledge their significance in viral infection-associated cancers has not been investigated.

To the best of our knowledge, the significance of the proliferative DR (PI-DR) and the correlation between PI-DR and the expression of HPC markers in terms of HCC prognosis has not been studied in detail.