Sentence examples for significance of localization from inspiring English sources

The physiological significance of localization of Cx45 within the superficial dorsal horn or whether Cx45 is assembled into functional gap junctions remains to be resolved.

JIP1 has been shown to localize to neurites in various neuronal models, but the functional significance of this localization is not fully understood [1 4].

The significance of nuclear localization of BRAFV600E has not been fully understood.

We examined the clinical significance of intracellular localization of BRAFV600E in cutaneous melanoma.

While the significance of nuclear localization of CBS is not known, it is pertinent to ask if the next enzyme in the pathway, CSE, is subjected to sumoylation and therefore also has the potential to relocate to the nucleus under some conditions.

The pathophysiological significance of nuclear localization of FLCN is poorly understood, and further study is needed.

Thus, the pathological significance of the localization of these molecules in NASH livers remains unclear.

One open question is the physiological significance of the localization of OCRL at endocytic clathrin-coated pits.

Although providing a further marker for B identity, the significance of the localization of the enzyme in maize leaves remains unresolved.

This is the first study to our knowledge to report the significance of abnormal localization of ezrin protein in uterine cervical cancers.

Another major question that remains to be answered concerns the physiological significance of the localization of SCVs in the MTOC/Golgi region.