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The expression patterns and clinical significance of class I HDAC isoforms were assessed by immunohistochemistry in a cohort of 43 hepatitis B virus-associated HCC patients treated with liver transplantation.
More vigorous investigations are needed to determine whether activation of PI3K-C2α or the related PI3KC2β occurs in response to other chemokines and to determine the functional significance of class II PI3K activation in macrophages.
To investigate the significance of Class I HDACs (HDAC1, HDAC2, HDAC3, and HDAC8), HDAC11, and Klfs (Klf1, KLf3, Klf4, and Klf7) in the pathogenesis of human leukemia, we used real-time RT-PCR to evaluate the expression of HDACs and Klfs in bone marrow samples from human leukemia patients.
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Rating (r) reflects the significance of classes which vary from 1 to 10 within each parameter and Weight (w) designates the importance for the parameter, and ranges between 1 and 5 (Fortin et al. 1997; Fritch et al. 2000; Knox et al. 1993).
We also present a Gene Ontology analysis of the periodic classes to further confirm the biological significance of our class division.
The third approach to aesthetics begins with a class of aesthetic objects and attempts thereafter to show the significance of that class to those who selectively respond to it.
The significance of the class of operation has to do with the amplitude linearity of the amplification process.
Significant cross-validated correlation coefficients q2 (0.558) and r2 (0.992) for CoMFA were obtained, indicating the statistical significance of this class of compounds.
The significance of this class of editing on protein functionality is self-evident.
The statistical importance of the signal P is described by two key quantities, the strength and the significance of the class representing P through its CR.
The significance of this class of alkaloids in the defense response against pest and pathogen attack is well known [ 30- 32].
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