Sentence examples for significance of binding from inspiring English sources

However, there are few studies to assess the biological significance of binding hot spots.

Statistical significance of binding for each PAB variant compared to the binding of parental wild-type ABD-TolA control is provided by ANOVA and shown by asterisks.

We assessed the statistical significance of binding site losses and gains by combining evidence across transcription factors, using a model for two correlated binomial distributions (Kostka et al., in prep .. Enrichment analyses were performed as above.

GSCA predicts likely upstream regulators for lists of genes based on statistical significance of binding event enrichment within the gene loci of a user-supplied gene set.

Additional work will also be required to understand the functional significance of binding of mutant FUS to stress granules, which have a role in cell viability and recovery after stress (11, 19, 20).

It does, however, reduce the significance of binding affinity scores for promoters whose GC content is similar to that of the motif, which has been suggested to be important when using DNA-binding scores in gene set enrichment analyses (Sinha et al., 2008).

Here, we report a unified statistical framework similar to that used in sequence and structure comparison (Levitt and Gerstein, 1998) where the significance of binding-site similarity can be estimated at least two orders of magnitude faster than for the original non-parametric method.

One of the biological significances of binding to the lumenal domain of the mannosyltransferases would be that adaptors may be inhibiting the enzymatic activity of the mannosyltransferases by associating with the catalytic domain during their exit from the ER.

As with CD36 binding, the pathophysiological significance of ICAM1 binding is unclear.

Several studies have reported transcription factor binding outside the typical promoter region [ 51, 52], but the extent and biological significance of such binding events have generally been studied less often.

To determine the functional significance of Spc105p binding to MTs it will be necessary introduce specific disrupting mutations into the putative MT-binding interface, a task that should be aided by ongoing crystallographic studies.