Variants of uncertain significance remain a problem, particularly in BRCA2, but truncating mutations are clearly associated with a markedly increased risk of breast and ovarian cancer.
The authors first illustrated the significance of the problem with a two-secondary-user game.
Despite this, there is a paucity of understanding of burrow distribution, biophysical controls and the potential significance of this problem beyond a small number of local studies at heavily impacted sites.
The existence of periodic and almost periodic solutions of differential equations has an important theoretical and practical significance and is a problem of great interest.
As an indication of the significance of this problem, it has been shown that depression poses as great a risk for mortality as does smoking, even when controlling for blood pressure, alcohol intake, cholesterol and social status [ 8].
The move by the government and the public in UAE towards how to deal with disaster is a clear indication about the significance of the problem.
This is a testament to two things -- the significance of the problem and the limitations on what presidential power can do to alleviate it.
To make things tougher, the significance of the problem can only be explained by using equations, symbols and mathematical terminology.
Meanwhile, Pentagon officials seem to underestimate the significance of the problem -- they are treating the Hilla exhumation as one that meets the needs of the Iraqis.
"We need to find better ways to compel individuals and organizations to address the significance of the problem of antibiotic overuse," they wrote.
