Respective Fisher tests and confidence intervals were then performed at the local 5%% significance level without correction for multiplicity.
The fit of the bivariate threshold model to the blood-injury, social and agoraphobic fear data was good; almost all RMSEA's were <0.05 and all P values exceeded the 0.002 significance level (Bonferroni correction for multiple testing).
It was the gene with the highest fold change in pCR cases as compared with non-pCR cases in both cohorts and lowest significance level after correction for multiple testing.
For each drug class beta-blockers, Aclass beta-blockersetics, stACEns and finhibitors analyzediureticsabolic datastatinsidentify metandlites whose blood serum levels signifibrates weffer between subjects tanalyzedd notheaking the respective drug (p value smetabolican 3.39 × 10−5, the estimatedatasetficance level aftor correctidentifymetabolitessting—see " Statistical analysis").
However, when we analyzed the impact of pairs of codons in the levels of CD4+T cells, the epistatic effects of five pairs of amino acids (i.e., 78 154, 85 154, 101 157, 105 157, and 105 176 pairs) were detected at a 5% significance level after correction for multiplicity (orange dashed lines in the Figure 1).
In a similar vein, although we attempted to correct for multiple comparisons by adjusting our significance level, true corrections (e.g., Bonferroni) were not applied, though this should be done in comparable future work.
The interaction between anxiety and optimism was not significant, at the significance level with Bonferroni correction (p = 0.0476).
For the dimensions MH (p = 0.0365) and GH (p = 0.0300), interaction was not significant at the significance level with Bonferroni correction (alpha risk of 0.006).
Appropriate significance levels, after correction for multiple testing, at the chromosome- and genome-wide level were estimated using the permutation procedure (1151 permutations, as there were 1151 animals) available in the GenABEL package.
