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Although up-regulation of PER1 transcripts did not reach statistical significance, expression of the protein gradually increased as the decidual process unfolded.
To determine if our findings had any functional significance, expression patterns for these genes were determined by real-time PCR experiments and the findings were correlated.
Although this systemic change in miRNA expression in PBMCs of AD patients is of prime significance, expression profiles in PBMCs may also indicate changes in the immune system in Alzheimer's disease [ 42].
p < 0.05 indicates significance Expression of in vitro dysregulated microRNA-376a, microRNA-330-3p, microRNA-330-5p, microRNA-422a, microRNA-455-3pmicroRNA-486-5p, anotmicroRNA-486-5p differt differ between PDAC and control.
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In addition, we detected a significant elevation of DNA fragmentation percentage, marked DNA laddering, and significance over expression of both caspase-3 and Bax proteins.
The significance of expression compared to WT with the P value less than 0.05 and 0.01 are marked by * and **, respectively.
The significance of expression compared to 0 h at P values of less than 0.05 and 0.01 are marked by "*" and "**", respectively.
The functional significance of expression of IL-1R1 and TNFR2 on Tregs is less clear.
The correlation significance of expression profiles between probe sets was assessed empirically by one hundred rounds of random permutations.
Student's t test was used to assess the significance of expression difference from normal and tumor tissues.
We do not require precalculation of the statistical significance of expression values.
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