Irrespective of the statistical significance, increasing duration of detention is negatively correlated with QOL.
However, urine angiotensinogen levels were positively correlated with significance for duration of diabetes, systolic blood pressure, BUN, serum creatinine and UACR, but negatively correlated with estimated GFR (Tables 2 and 3).
Extracted data consisted of the study characteristics (first author, journal and year of publication, drug name, number of patients enrolled/included, primary end point with its statistical significance, study duration), some of the patient characteristics (mean age, proportion of men) and the outcome of interest.
This may be explained by the fact that other factors are more significant and dilute the significance of diabetes duration.
This study demonstrated the significance of treatment duration on the relative cost-effectiveness of the therapies.
In patients with disease more than 13 years, the statistical significance of disease duration disappeared.
The remaining significance of diabetes duration could be the result of incomplete control for complications (e.g., microalbuminuria, retinopathy, and neuropathy are not included).
The significance of treatment duration on disease outcome has also been shown for small laboratory animals such as mouse and hamster, and man [ 1, 29, 30].
A follow-up study involving a larger number of cases would allow a more accurate evaluation of the significance of the duration of onset of clinical signs.
In these six patients, the mean anti-HBsAb titre at baseline was significantly lower (P = 0.006), and although it did not reach significance, the mean duration of anti-TNF therapy was longer (P = 0.09) as compared with patients who did not present a decrease in anti-HBsAb.
