James DeRosa praised Anthropy for her implementation of elements and ideas that most games do not cover and called it a "hypersexualized, bondage-themed platformer" with which Anthropy "explores the power dynamics of sexuality and disassembles essentialist male and female sex roles as portrayed in video games -- as well as the significance of difficulty and reward as a design method".
Previous-day 24-hr average O3 also approached statistical significance with difficulty breathing (OR = 1.49; 95% CI, 0.96 2.32).
For paediatric ICUs the 48% reduction did not achieve statistical significance; the difficulty of reducing CVC-BSIs in paediatric intensive care is well recognised.
Taking this position ignores the significance of difficulties and challenges one faces when they are the only one within their department, college and/or university.
Although the number of GWASs has grown dramatically during the last five years [ 36, 37], GWASs have several limitations, such as small sample size, dependence on minor allele frequency and genetic effects, stringent statistical significance, and the difficulty of replication across studies [ 38].
The significance of these difficulties is that the context for how delay is counted and captured needs to be understood.
T-tests were used to test significance of the labeled difficulty effect within each level of actual difficulty.
They see reform of state-owned industries or of financial services as technical issues, when in reality the difficulty, and significance, of reform lies in the fact that these sectors are products of a rotten social and political order.
In a review done by Vargo, he has stressed the significance of unrecognized respiratory difficulty and hypoxemia as a major factor contributing to morbidity and mortality among patients with PSA in the ambulatory setting.
The difficulty and significance of the game's final boss, the Creator, has elicited several mentions.
