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Among 13 profiles with significant numbers of associated proteins in Desiree, we found five profiles (number 26, 11, 9, 1, and 12 in order of significance) containing in total 156 proteins with lower abundance in the apoplast.
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This plot reveals the amount of significance contained in SGoF against the intersection null, for each γ value.
Patterns of uncertain significance contain graphoelements/EEG patterns that resemble abnormal ones, but in most of the cases they are not associated with a pathologic process ("normal variants").
Applying the same strategies for the 38 genes overexpressed in the fibrosis group, the functional groups with the highest levels of significance contained much fewer genes (2 to 7 per group, P < 0.049; Figure 5) which, surprisingly, were not related to matrix production/clearance.
The "Significance" panel contains all the parameters for the evaluation of the statistical significance of a motif subnetwork.
Based on manual survey of publications, we found that several previously implicated genes with clinical significance were contained in these two subnetworks.
The network with the highest significance also contained several cancer-related genes with high expression levels, including DSG2, PRKCA, PLA2G10, and Grp94.
There were, however, a few remaining pathways that maintained their significance and contain genes that have an implicated role in Crohn's disease.
These results suggest the significance of species containing an odd number of carbon atoms in PAH formation processes in the methane flame, as well as the importance of soot surface reactions.
CRP was independently associated in a model adjusted for female sex only, but lost significance in models containing MMP-8 or MMP-9 levels.
MMP-8 and MMP-9 levels were not independently associated since both lost significance in models containing both MMPs as independent variables.
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