Although the number of GWASs has grown dramatically during the last five years [ 36, 37], GWASs have several limitations, such as small sample size, dependence on minor allele frequency and genetic effects, stringent statistical significance, and the difficulty of replication across studies [ 38].
James DeRosa praised Anthropy for her implementation of elements and ideas that most games do not cover and called it a "hypersexualized, bondage-themed platformer" with which Anthropy "explores the power dynamics of sexuality and disassembles essentialist male and female sex roles as portrayed in video games -- as well as the significance of difficulty and reward as a design method".
These include similarities beween the PWMs used to predict TFBSs, biases caused by motif over-representation, and difficulty of evaluating the significance of observed co-occurrences using standard statistical tests.
Many limitations can be found to the current validation testing, including relevance of the questions, validity and sensitivity to change, risk of misinterpretations (role of the ethnocultural environment), problems of translation of English questionnaires and difficulty to interpret the significance of a psychometric measurement when reported simply as a numerical score or a mean [ 1, 2].
Taking this position ignores the significance of difficulties and challenges one faces when they are the only one within their department, college and/or university.
Previous-day 24-hr average O3 also approached statistical significance with difficulty breathing (OR = 1.49; 95% CI, 0.96 2.32).
For paediatric ICUs the 48% reduction did not achieve statistical significance; the difficulty of reducing CVC-BSIs in paediatric intensive care is well recognised.
Dental pain and difficulty chewing were more prevalent among children with treated teeth than those with no TDI, but this difference did not achieve statistical significance (P > 0.05).
Pain and difficulty swallowing.
Pick a character to play and difficulty.
