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Two pathways show a highly significant association within Chin et al. alone and 4 pathways show significance across multiple data expression datasets.
We show that predicted miRNA-target associations that retain significance across multiple cancer types involve a number of critical tumour suppressor genes and oncogenes.
Not surprisingly, the beta-hemoglobin gene associated with sickle cell anemia and beta-thalassemia, and the ABO blood group polymorphisms, have achieved genome-wide significance across multiple malaria studies.
We quantified this effect using scanning densitometry (Fig 2D) and confirmed its statistical significance across multiple independent experiments (Fig 2E).
Signatures that provide true prognostic value should demonstrate statistical significance across multiple datasets.
QTL were detected by Brouwer et al. (2004) on all twelve chromosomes, with some QTL showing significance across multiple assay methods and environments.
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Bonferroni corrections were used to adjust significance thresholds across multiple tests.
Notably, the current study was not powered to conduct traditional significance testing across multiple dependent measures, hence the exclusive focus on the study's primary continuous outcome measure, the blind IE-rated NIMH TSS scores.
Mixed-model ANOVA was used to assess the significance of change across multiple time points.
A challenge for future research is to understand the mechanisms and significance of integration across multiple frequencies of brain rhythms, and between LFPs and single cell activity, during decision making and different prediction error states (e.g. Hyman et al., 2010; Buzsaki and Wang, 2012; Lisman and Jensen, 2013).
Analysis was done using the t-test method for determining significance of CRX expression across multiple datasets for normal and cancer cell lines.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com