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Then, we discriminated putative HT sequences from the sequences displaying a signature of functional constraints.
The design of Clade models makes them better able to detect this alternative signature of functional divergence.
This result is consistent with the results from Casillas et al. (2007) where 38.6% of the noncoding DNA in D. melanogaster display the signature of functional constraints.
First, our system permits to single out those reactions, well confirmed experimentally, that turn out to be highly specific as a potential signature of functional or evolutionary impact.
The transaminases, the cyclohydrolases, the oxidoreductases and the hydroxymethyltransferases define the signature of functional classes over-represented in the two types of oxidative stresses.
Accordingly, this rare conservation of gene order has been interpreted as the signature of functional relationships between the products of these stably associated genes [ 8- 14].
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In polar bears, genes demonstrating signatures of functional divergence and those potentially under positive selection were enriched in functions related to production of nitric oxide (NO), which can regulate energy production in several different ways.
Our analysis revealed two signatures of functional selection: reading-frame compatibilty and non-random co-occurrence of protein domains.
In conclusion, we identify two signatures of functional selection in oncogenic fusion proteins: specific combinations of protein domains and reading frame compatibility.
This finding suggests that the EEG frequency bands indeed can be seen as electrophysiological signatures of functional networks as often argued in the EEG research.
Even if our findings are not at present entirely applicable to solid tumors, we believe that the two signatures of functional selection will be evident in expressed fusion proteins of most cancer types.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com