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It is tempting to suggest an inability to develop or fully utilise such emotional biasing signals to explain apathy symptoms.
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We therefore neglect all dispensable network elements and focus on BMP signaling to explain digit patterning.
In light of the presence of digits without Shh/Gli3, and the absence of digits in BMPR1A and SMAD4 conditional mutants we focus on BMP-dependent signaling to explain the observed patterning of Sox9 in the limb bud.
Next, we examined how 17AAG might modulate Nutlin-induced p53 signaling to explain its synergism in promoting Nutlin-induced apoptosis.
However, even if sufficient data are available, it is challenging to construct a model of cell signalling to explain the data and make accurate predictions.
Combination therapy has been shown to provide enhanced antitumour activity; however, the downstream signalling to explain how these drugs mediate their response is not clearly understood.
[ 32], although we would suggest that both mature (duplication competent) and immature centrioles would have to be able to generate such a signal to explain the mutual interference observed in our experiments.
Papers that develop models to estimate latent signals or to explain observed phenomena are encouraged to submit for this topic.
Figure 1 summarizes our current concept of a signaling mechanism to explain agonist-induced Ca2+ entry in the pancreatic acinar cell.
David Lewis (1969) introduced signaling games to explain how messages can be used to communicate something, although these messages do not have a pre-existing meaning.
Our current findings present an additional novel signaling pathway to explain the diverse roles of Gαo and cannabinoid receptor.
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