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This finding emphasizes that signal-to-response relationships will in general require multiple signaling pathways to be included in the model and that attempts to predict how cells will behave on the basis of alterations (whether genetic or therapeutic) to a single component or pathway will most probably be in vain.
The company said 170 areas from around the UK with little or no mobile signal applied to be included in the trial.
Can we then identify archetypal properties of signaling networks necessary to be included in our models, striking a balance between predictive power and mechanistic representation of the biology?
On first sight, via the catch-up service alone (I write outside of London and can't get the signal, so am happy to be included in the other 80% of the British population), it's unashamedly youth-oriented, featuring shaky hand-cams, disjoins, much urging towards Instagram and Twitter and other such fripperies that no one under 35 and possessed of a brain can apparently do without.
Hence, these cells do not provide signal with sufficient quality to be included in the active set.
As the epicenter was located far away from the island, GPS coseismic deformation data did not have sufficient signal-to-noise ratio to be included in the joint inversion.
For chenodeoxycholic acid and its dimer, the three lowest mass isotopologues produced signals of sufficient strength for them to be included in the analysis; for the remaining compounds only the two lowest mass isotopologues were included.
The effects of Tim1 mutations on the distribution of signaling molecules should be included to support tyrosine phosphorylation data.
Recently developed mixed blocked/event-related designs allow task set-related signals to be extracted in fMRI experiments, including activity related to cues that signal the beginning of a task block, "set-maintenance" activity sustained for the duration of a task block, and event-related signals for different trial types.
This has lead to the use of alternative analysis methods that do not require the signal to be stationary, including wavelet analysis and, more recently, the Hilbert-Huang transform.
We detected several proteins reported in interferon-gamma signaling to be overexpressed, including guanylate binding protein (GBP1), major histocompatibility complex protein (HLA-B), intercellular adhesion molecule (ICAM1), ubiquitin-like modifier (ISG15) and STAT1.
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