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Dr. Niklason's research focuses primarily on regenerative strategies for cardiovascular and lung tissues, and the impact of biomechanical and biochemical signals of tissue differentiation and development.
To protect the host and maintain tissue homeostasis, the immune system responds not only to a vast array of pathogens, but also to environmental cues, for example, signals of tissue injury or changes in nutrient availability.
This work has been presented at the 4th International HMGB1 symposium, "Signals of Tissue Damage", held in Helsinki, Finland, June 20 23th 2010.
These inflammatory responses may be generated in response to exogenous pathogen-associated molecular patterns and to endogenous signals of tissue and cell injury (alarmins).
TLRs have various functions as an important component of innate immune system by recognizing pathogen-associated molecular patterns and also endogenous signals of tissue injury [ 97].
This in itself should not induce proliferation unless cell-extrinsic signals of tissue damage such as inflammatory cytokines are also present.
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To make the inter-slide signals comparable, net signals of fifth-instar day 5 larvae were normalized on the basis of U6 and 5 S rRNA signals, and net signals of tissues during metamorphosis were normalized with a global-median method [ 60].
We showed previously that HMGB1 can be released passively by cells that die in a traumatic and unprogrammed way, and can serve a signal of tissue damage.
In this theory, what is essential for the immune system to react to an antigen is a signal of tissue injury, sensing the danger [15, 16].
Chronic pain is more like a difficult emotion than an acute signal of tissue damage.
As a signal of tissue damage, HMGB1 mediates tissue regeneration by inducing mesoangioblast migration and proliferation [ 36].
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