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Since angiogenesis is a complex, multi-step process, different signals may need to be delivered at appropriate times in order to promote a robust and mature vasculature.
Depending on the particular system, the isolation of one such signal may be sufficient, or both signals may need to be considered together to determine pathological relevance.
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Also, it is important to note that the datapath design also changes during this stage since certain datapath signals may needed by the control logic, or operation which where not discovered durring datapath development may be needed.
Accordingly, systems-level analyses of signaling may need to integrate multiple experimental and/or computational approaches.
Together, these data suggest that GCSF signaling may need to be inhibited to employ immunotherapy effectively in some established tumor settings.
Very little is known about the biological significance of this new ligand of CSF1R, but it appears that the concept of targeting CSF1/CSF1R signaling may need to be revisited.
For instance, the role of the AhR repressor protein in TCDD signaling may need to be considered [ 104].
According to an extension of the general auditory account that includes learning, the signal may need to have speechlike spectrotemporal characteristics, and thus compensation for LTAS would not be completely independent of more fine-grained temporal and spectral properties of the precursor signal.
Therefore, in the context of synthetic lethality, when signaling intensity may need to exceed thresholds to induce toxicity, a combination of mutation of one oncogene and amplification of another may not create mutual exclusivity even though other mutational combinations might do so.
Other carmakers, including BMW and Toyota, have signalled that they may need to shift production out of the UK should parliament opt for a no-deal Brexit.
Julia Gillard has signalled that countries may need to review their intelligence systems in the wake of revelations this week about Australia's attempt to listen in on the mobile phone of the Indonesian president, his wife and a group of prominent Jakarta MPs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com