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These operational signals may act on different time scales than the functional modes.
Some Wnt signals may act as developmental switches that lead to long-term or permanent transcriptional reprogramming in target cells.
Moreover, S. cerevisiae Ssn3 has been found to inhibit filamentous growth by phosphorylating Ste12 when cells are growing in rich medium [57], suggesting that nutritional signals may act through the C-type cyclin/CDK pair to regulate filamentous growth.
We speculate that photoperiod signals may act on the hypothalamus to establish this refined pathway, whereas socially-mediated increases in gonadally derived testosterone may feed back on the hypothalamus and other brain regions to assist in maintaining it through the spring.
At normal intensity levels, such amino acid neurotransmitter signals may act on valence-coded locations in rostral medial shell to help give healthy attractiveness to rewards and zest to life, whereas at excessively higher levels may contribute to compulsive drug addiction and related compulsive pursuits [56], [60].
dpp and daw, as secreted signals, may act systemically to regulate other target genes in other tissues throughout the animal.
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These data indicate that VDR ablation alters susceptibility to DMBA-induced carcinogenesis in a tissue specific fashion, and provide support that optimal VDR signaling may act to suppress tumorigenesis.
This suggests that FGF2 signaling may act on HIF-1α induction, as shown in recent reports [27], [28].
Similarly, in the mammalian cochlea, GABAergic signaling may act synergistically with nicotinic cholinergic signaling in shaping peripheral output and multi-tiered stages of postnatal development dependent on precise aspects of neural activity.
Interestingly, in follicle cells mer produced a much stronger phenotype than ex, indicating that the upstream signal may act mainly through mer to regulate the Hpo pathway in follicle cells and that ex facilitates mer in transducing this signal.
Observations that p130Cas SD tyrosine phosphorylation occurs primarily within mature FAs located away from the leading edge [19], [22] suggest p130Cas signaling may act to regulate FA dynamics during cell migration.
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