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Natural extracellular matrix offers a perfect microenvironment for biochemical, topographical and electric signals for cell attachment, proliferation and differentiation.
Native ECM possesses appropriate mechanical properties for physiological function of the biomaterial and signals for cell binding, growth and differentiation.
It allows for detailed study of the regulation of neurogenesis, determinants of cell fate specification, and signals for cell survival versus programmed cellular death during development.
The porous scaffold provide the cells with an adequate biomechanical environment that allows mechanotransduction signals for cell differentiation and the scaffolds also protect the cells from initial compressive loading.
Chemokines bind to seven transmembrane-spanning receptors that are coupled to heterotrimeric guanine nucleotide-binding (G) proteins, which are the responsible for intracellularly transmitting the activating signals for cell migration.
The PDGFR system, located primarily on mesenchymal cells, transduces signals for cell survival, growth and chemotaxis.
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Three-dimensional scaffolds play an important role in tissue regeneration by providing attachment sites as well as bioactive signals for cells to grow and differentiate into specific lineages.
These findings indicate that cytosolic SYT functions in the cytoskeletal machinery used to differentiate among extracellular signals for cell-matrix adhesions.
Multi-cellular organisms such as plants and animals use cell surface receptors to sense and transduce chemical signals for cell-to-cell communications.
(a) Quantitation of fluorescent signal for cell spheroid viability assay.
Weijers, D. et al. Auxin triggers transient local signaling for cell specification in Arabidopsis embryogenesis.
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