Moreover, G12 G-proteins signal extensively through downstream RhoA GTPases35, which our earlier findings had already implicated in Atrx-deficient mNPC motility (Fig. 3d f).
Auxin related gene family has earlier been implicated in mediating auxin signaling extensively and controlling almost all the processes from embryogenesis to flowering [17].
For instance, among the selected genes were phosphatidylinositol 3-kinases, a gene family involved in multiple cellular functions related to cancer, or MRAS, part of the Ras signalling extensively dysregulated in carcinogenesis (Bunney and Katan, 2010).
EEG signals were extensively analyzed in the space×time×frequency domain with a multivariate nonparametric cluster randomization test.
The role of lipid rafts in signaling is extensively documented, as they function as physical platforms capable to assemble the signal transduction machinery [21] [23].
Inhibition of activated β-catenin by small molecules decreases canonical Wnt signaling which extensively rescued the erythroid maturation defect seen in Mtf2-deficient HSPCs and pro-erythroblasts, as demonstrated by both colony forming and ex vivo maturation assays, respectively.
Dopamine receptor mediated signaling is extensively regulated by numerous processes, including, endocytosis, whereby agonist activated receptors are rapidly silenced by removal from the cell surface to an endocytic compartment.
Crosstalk or reciprocal regulation between hormone-dependent pathways, including ERα- and AR-mediated signal transduction, and NF-κB signaling has been extensively established at multiple signaling nodes [43], [44], [45].
Crosstalk between different signaling pathways occurs extensively and forms a complex signaling network that enable cells to interpret multiple inputs and execute different responses in a context-dependent manner.
The relationship between oxidative stress and calcium signals has been extensively studied, given the pathological relevance of the field [ 19].
The feed-forward loops in accelerating transductions of signals have been extensively studied (Milo et al., 2002; Shen-Orr et al., 2002).
