Sentence examples for signals arrest from inspiring English sources
In general, growth inhibiting signals arrest the cell cycle by blocking cyclin dependent kinase (CDK) activity through the actions of cyclin dependent kinase inhibitors (CKIs) such as p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 [5], [5].
For MNNG, MLH1 signals arrest in conjunction with the phosphatidylinositol 3-kinase-like kinases Ataxia telangiectasia mutated (ATM; Adamson et al, 2005) and ATM- and Rad3-related (ATR; Stojic et al, 2004).
Recently, a novel bis-anilino pyrimidine inhibitor, TAE226, was reported to efficiently inhibit FAK signaling, arrest tumor growth and invasion and prolong the life of mice with glioma or ovarian tumor implants.
Gattinoni, L. et al. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells.
Thus, the inhibition of NOTCH signalling arrests proliferation but it is not sufficient to elicit neuronal differentiation.
A role for BMP4 in mesendoderm specification has also been clearly demonstrated by genetic studies in the mouse showing that absence of BMP signalling arrests the development of embryos at the early gastrulation stage [30] [32].
Could CRK10 signaling arrests the cell cycle to control the spread of infection?
Wnt/β-catenin signaling arrests CD8+ T-effector cell terminal differentiation, preserves naive T cells and induces the generation and maintenance of central memory CD8+ T cells.
The lysis proteins of JG068, encoded on the far right end of the genome, include a putative pinholin, signal-arrest-release (SAR) endolysin, Rz, and Rz1.
Similar to the signal-arrest-release (SAR) endolysin of ϕKMV, inducible expression of the JG068 SAR endolysin causes lysis of Escherichia coli that is dependent on the presence of an N-terminal signal sequence.
This is achieved through MAPK activity downstream of the brachyury-FGF feedback loop, and we postulate that MAPK signalling arrests the development of mesoderm precursors in the VMZ to maintain germ cell potential (Fig. 7F).
