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Changes in Bmp and Wnt signalling were observed during tooth development in both Lrp4 and Wise mutants.
The possible primary role of Fgf signalling in supernumerary tooth formation in Lrp4 mutants can be excluded since no changes in Sprouty expression or Fgf signalling were observed (data not shown), suggesting that the Bmp/Shh interaction lies downstream of Fgf signalling.
B- and T-cell receptor-mediated signalling were observed to be decreased in CMCs, which can be explained by the lower number of these cell populations in the CMC samples as shown by the flow cytometry data, and is in agreement with an earlier study [16].
Similar impairments in insulin signalling were observed in vivo in adipose tissue, liver, and muscle in HFD-fed apoE−/− /CD36−/− vs. apoE−/− mice (not shown).
Terms that indicate processes involved in signalling were observed exclusively in N. vitripennis both immediately after conditioning and at later time points, whereas a number of terms that indicate cell regulatory processes are unique for N. giraulti.
In one study, mutations in β-catenin were observed in only 2 of 37 total melanoma cases, and mutations in APC, a negative regulator of β-catenin signalling, were observed in only 1 of 37 cases (Reifenberger et al, 2002).
Similar(53)
No signals were observed from normal HDFs (Fig. 2a).
Similar signals were observed almost 90 years ago on Japanese volcanoes.
YFP and RFP signals were observed with an Olympus FV1000 confocal laser scanning microscope.
No OMV signals were observed in control cells incubated for 24 h with OMV buffer instead of OMVs (Fig. 4g).
In the years that followed similar signals were observed in the Cascadia subduction zone off the coasts of Oregon and Washington.
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