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It is both of central and peripheral origin due to impaired cholinergic signalling upon inhibition of acetylcholinesterase (AChE).
Signalling upon TCR stimulated by MHC presented antigen induces IL-13 production, antigen-specific Th2 response and expression of anti-apoptotic genes through NF-κB translocation [77].
This model did not yet include the negative feedback regulation of CLV3 signalling upon WUS expression, and the creation and maintenance of the WUS domain was not simulated.
We observed significantly increased luciferase expression of cells transiently transfected with commercially available constructs initially designed to investigate Jak-STAT-mediated IFN signalling upon infection with different herpesviruses.
As Erk5 has been shown to participate in proliferative signalling upon activation of HER2 [14], we explored whether a correlation existed between Erk5 expression levels or activation and HER2 expression in the patient series.
Calreticulin-deficient (crt−/−) T cells display an altered regulation of calcium signalling upon TCR stimulation, which results in protracted nuclear translocation of nuclear factor of activated T cell (NFAT) and activation of the mitogen activated protein kinase (MAPK) pathway.
Similar(23)
Three of thirty probes produced hybridization signals upon hybridization with seawater samples from PHS.
This module successfully transmitted an alarm signal upon detection of a fire in the feasibility test.
Four of the 30 probes generated signals upon hybridization with seawater samples from PDS (Fig. 3b).
Electrochemical signals upon thermal denaturation undoubtedly designated the presence of a complementary sequence.
So while there is negative signaling risk of talking about an ICO, there is definitely the potential for positive signaling upon successful completion.
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