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However, only signalling up to CheY-P was considered.
Although not understood in detail, this positive feedback loop is believed to intensify the level of Kras signalling up to a threshold necessary for transformation of pancreatic acinar cells (Ardito et al, 2012; Navas et al, 2012).
In contrast, statistically significant effects between TRPM2-overexpressing cells and controls were not obtained when 8-Br N-cIDPR was used as activator of Ca2+ signalling up to extracellular concentrations of 10 mM.
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TLR4 signalling up-regulates TLR2 in LPS (lipopolysaccharide -stimulated macrophages, suggesting that the cross-talipopolysaccharide -stimulated as a positive feedback loop [ 29].
Our study in A549 cells revealed that receptor EphA2 signaling up regulates the TJ protein claudin-2.
A diver who signals "Up" to his buddy should receive the "Up" signal in return so that he can be sure that his signal was understood.
For the next-obsessed traveler, pioneer communities signal up-and-coming places, as in, "South African wine pioneers have really changed Tulbagh -- it's the new Stellenbosch".
We also show that, reciprocally, β-catenin/TCF signaling up-regulates expression of endogenous UCH L1 mRNA and protein.
Furthermore, persistent activation of ERK signaling up-regulates TDAG51.
10.7554/eLife.00780.011 Figure 4. p38MAPK cell signaling up-regulates U6atac level and minor intron splicing.
Moreover, VEGF signaling up-regulates tissue factor mRNA, protein and procoagulant activity [ 10].
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