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33 Therefore, we tested the hypothesis that CXCR2 signalling supports SOX9 expression via AKT activation.
If CXCR1/2 signalling supports SOX9 expression, why did we not observe spontaneous osteoarthritis in CXCR2-deficient mice?
The enrichment of our database with proteins that have a predicted function in transport and receptor signalling supports the reliability of our approach.
Our findings that CXCR1/2 signalling supports cartilage homeostasis are not at odds with the well-established pathogenic role of ELR+ CXC chemokines in arthritis.
These results confirm that CXCR2 signalling supports articular cartilage homeostasis in vivo in conditions of challenge and demonstrate that its disruption is associated with more severe OA.
In support of this notion is the observation that MAPkinase signalling and IBMX (enhances protein kinase-A signalling) supports early, but not late, adipogenic differentiation (Student et al, 1980; Kortum et al, 2005).
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The response on social media was positive, with the official Barack Obama Twitter account signalling support.
Today, however, he dooms Mr Clegg's stand by signalling support for the latest Tory trapdoor to prison, while whispering soothing words about getting the details right.
Signal supports and encrypts all of your messages, calls and video chats with other Signal users.
Every cluster has its own signal template that differs in the signal supports.
It is not very informative regarding the quality of the recovered signal supports.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com