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Irreverent, whether in an institutional setting or not, signalling reversible orders.
Poetry: "Irreverent, whether in an institutional setting or not, signalling reversible orders".
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It has been hypothesized that sensation of α-ketoglutarate and adenylylate energy charge represent ancient and highly conserved functions of PII, while transmission of a glutamine signal or other signals by reversible covalent modifications of PII represents a more recent modification to the core regulatory system (3).
The increase in oxidation of catalytic Cys in phosphatases detected in the mutant MEFs is likely to have wide-ranging effects on signalling by reversible phosphorylation.
Phosphatases that possess a critical cysteine residue in their active site can mediate redox signalling through reversible oxidative inactivation [ 15, 16].
In this model, PP2C serves as a central and negatively regulated hub in ABA signaling [ 8] and the first connection of the ABA signaling with reversible phosphorylation.
This is the simplest reversible signalling network one can consider for spatial signal processing.
However, the knockdown of FST did not alter BCAS2 protein levels, which showed that this signalling was not reversible and that FST was downstream of BCAS2.
A powerful tool to regulate signalling is the reversible modification of proteins with ubiquitin chains, as it can alter the localization, activity or stability of modified substrates (Kerscher et al, 2006).
Redox signalling is a reversible phase of physiological regulatory reactions occurring over shorter time periods; they concern primarily the main cellular redox systems, for example, GSH, ascorbate, vitamin E, lipoic acid, NADPH, or NADH.
In Xenopus, changes in Ca2+ signaling epitomize such remodeling: The reversible Ca2+ signaling phenotype of oocytes rapidly adapts to support irreversible propagation of the fertilization Ca2+ wave.
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