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Together, these data indicate that PKCζ activation downstream of NMDAR activation is a fundamental component of LTD signalling, regulating the activity of NOX2 via p47phox.
Importantly, the number of spermatogonial generations, i.e. the number of mitoses spermatogonia undergo before meiosis, and the signalling regulating their differentiation is more specific to each species.
In Pirellula staleyi FtsZl1 is associated with Psta_0487, a diguanylate phosphodiesterase, involved in cyclic diguanylic acid (c-di-GMP) signalling, regulating e.g. motility, biofilm formation and virulence.
In epithelial cells, GEF-H1 activates RhoA signalling, regulating paracellular permeability, junctional dynamics and proliferation (Benais-Pont et al, 2003; Aijaz et al, 2005; Ivanov et al, 2005).
Mammalian target of rapamycin is a downstream mediator of PI3K/AKT signalling, regulating proliferation, survival, mobility, and angiogenesis via targeting p70S6 kinase (p70S6K) and 4E-BP1 in breast cancers that exhibit constitutively activated PI3K/AKT signalling (Bjornsti and Houghton, 2004).
The data presented here demonstrate a hitherto unrecognised function for dpn and E spl)C in mediating, at least in part, the function of Notch signalling regulating cell proliferation during wing disc development.
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Extended Data Fig. 4 Sialic acid-CD22-SHP1 signalling regulates phagocytosis.
Androutsellis-Theotokis, A. et al. Notch signalling regulates stem cell numbers in vitro and in vivo.
Plikus, M. V. et al. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration.
Heit, J.J. et al. Calcineurin-NFAT signalling regulates pancreatic beta cell growth and function.
Barnette, D. N. et al. iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction.
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